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Specialist article
08.07.2024  |  184x
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From process development directly to contract manufacturing

With short time-to-market: Particle and functional design from the fluid bed market leader

The Glatt Group’s customers benefit from bundled expertise in particle design – from the initial feasibility test, through scale-up, to validation of the production process. Glatt offers suitable solutions for every variant and, if required, also implements customer-specific processes.

Contract manufacturing has to fulfill very varied requirements. Some companies permanently outsource their production and permanently request large quantities. Others require flexible production slots to compensate for highly fluctuating requirements in terms of volume. Often, a mature product idea exists, but the innovators do not yet have the suitable technology. For the production and refinement of solid product formulations, a wide variety of tasks are commonplace: from nanodispersed powders for high-tech applications, to matrix-encapsulated feed and food additives in granule and pellet form, to products with a modified release of active ingredients.

Contract manufacturing is always preceded by product and process development. As a pioneer in fluid bed technology, Glatt has gained extensive experience and developed expertise in all areas of process and product development. And it is precisely this expertise from which customers benefit. Glatt process experts know the strengths and weaknesses of fluid bed technology very well and can therefore tailor the formulation and process to fit together precisely. This shortens the development time and the customer can concentrate on his core competence, the actual product. The aim of most Glatt Ingenieurtechnik customers is to invest in their own production plant. The intermediary step of contract manufacturing increases the understanding of the manufacturing process and the specific production requirements on both sides. This provides additional security for the plant design. Knowledge gained through faster time to market consolidates planning and reduces the investment risk.

Analytics at the Glatt Technology Center Weimar

The expertise can be found in the details. As a plant manufacturer and operator, Glatt understands the entire value-added process and offers its customers unique services, from the product idea to the custom-designed production plant which is installed on site. Process development always starts with laboratory trials tailored to the customer’s formulation. In close collaboration and supported by a variety of analytical methods, the formulation’s suitability for practical use is initially tested in a feasibility study. This involves measuring the product data of the raw materials as well as the targeted particle size distribution of the desired product using a wide variety of methods: Starting with a traditional sieve analysis, through dynamic imaging techniques such as the Camsizer, to laser diffractometry, it is possible to measure the size and shape of particles from the nanometer up to the millimeter range. It is also possible to measure dispersed solids in liquids or emulsions. Such analytical data are essential for the development of a robust process. If a qualitative analysis of raw materials or products is required, elemental analysis and ICP-OES can be used to verify stoichiometries or detect impurities. This ensures the quality of raw materials and products.

Focusing on all relevant particle properties

When it comes to the absence of dust, pourability and other powder properties, Glatt Ingenieurtechnik provides methods for determining bulk density, angle of repose and other characteristics. The determination of size and flow properties may describe the product particles generated, but it does not show their exact detailed structure. This is where microscopy offers insights, in particular, the scanning electron microscope provides information on the exact agglomerate and particle structures in the micrometer range. If the focus is on crystal structures, Glatt can also offer X-ray diffraction (XRD) measurements to investigate the properties of the material in even greater depth.

Film thickness, film homogeneity and surface properties in particular provide important information for coating processes. When processing fat and wax melts for hot melt coatings, thermal properties such as melting and solidification behavior are important parameters which can be determined using differential scanning calorimetry (DSC). “Our customers value the analytical capabilities available in the Glatt laboratory, as these significantly reduce both time and effort in development. Test samples can be evaluated immediately and the findings can be used to plan further tests,” says Gudrun Ding, Head of Business Development. It is not only customers who can use the wide range of analysis options during the trial phase. Glatt also offers this analysis to third parties and is further expanding its capacities for contract analysis.

A network for research and development

The Glatt Technology Center in Weimar is linked to renowned scientific institutions such as universities and research institutes in Germany and abroad. Thanks to continuous research and development work in process engineering for the calcination, granulation and drying of powders and liquids containing solids and for particle coating using technologies such as powder synthesis, fluid bed or spouted bed, using its equipment Glatt is now able to develop and optimize products whose processing was virtually impossible just a few years ago.

Suitable scale-up solutions for fast market success

Scale-up is particularly important for the introduction of new products to the market. Especially for end consumer markets, several tons of product are needed very quickly. Using contract manufacturing at Glatt Ingenieurtechnik, the new powders, pellets or granules are produced, filled, packaged and delivered straight away in the agreed quantities. Glatt acts as a flexible and competent interface along the entire value chain. In this way, new products move more quickly from the development phase to market maturity, and larger investments in production capacity or personnel can be carried out at a later date when the product has successfully established itself in the target market.

Contract manufacturing expertise at Glatt:

  • Process and formulation development
  • Scale-up
  • Contract manufacturing / toll manufacturing, active refinement
  • Quality control and analytics (internal / external)

Specialized in:

  • Continuous fluid bed, spouted bed and high temperature processes
  • Processing of solvent based products
  • Liquid processing with high pressure homogenization
  • Focus on processes around particle design and engineering for the development, optimization, functionalization and production of powders, granules and pellets
  • Various physical analysis methods, SEM, elemental analysis
Industries: Food additives, dietary supplements, feed additives, fine chemicals

Author:
Gudrun Ding, Head of Business Development Process Technology, Glatt Ingenieurtechnik GmbH, Weimar, Germany

Originally published in the magazine ‘Pharma+Food’, Kompendium Lohnherstellung 2023, Hüthig GmbH

Company information

Glatt Ingenieurtechnik GmbH
Glatt Ingenieurtechnik GmbH
Glatt is specialized in intelligent particle design for the generation and functionalization of powders and granulates with defined, adjustable properties. The focus is on particles and powders for pigments, catalytic, ceramic or battery materials as well as for granules and pellets as additives for e.g. industrial salts, detergents and cleaning agents, fertilizers, pesticides, food, feed, dietary supplements and pharmaceuticals. Encapsulation of flavors, enzymes, vitamins, microorganisms, probiotics or fatty acids (PUFA) is just as possible as encapsulation of essential oils and other active, sensitive substances to be protected. With Glatt APPtec®, a unique technology for spray calcination, it is possible to generate, coat and then calcine particles in a pulsing hot gas stream in a single process step. As a pioneer in fluid bed and spouted bed technologies, Glatt masters these important processes for the formulation and optimization of particle properties through defined spray agglomeration, spray granulation, spray coating or (micro)encapsulation as well as through combinations of these processes. Also in the high temperature range. Glatt supports the product idea from the early phase of product formulation through process development to scale-up to production scale. Under the leadership of the Glatt Process & Plant Engineering teams, customized production plants for nutrition, fine chemicals, pharmaceuticals, and biotech applications are successfully planned and commissioned. Worldwide. Whether based on powder synthesis, fluid bed or spouted bed technology, Glatt also offers certified contract manufacturing for customers without their own production capacities.
Last update: 07.06.2024

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