Stabilization of Vitamins

Glatt is specialized in intelligent particle design for the generation and functionalization of powders and granulates with defined, adjustable properties. The focus is on particles and powders for pigments, catalytic, ceramic or battery materials as well as for granules and pellets as additives for e.g. industrial salts, detergents and cleaning agents, fertilizers, pesticides, food, feed, dietary supplements and pharmaceuticals. Encapsulation of flavors, enzymes, vitamins, microorganisms, probiotics or fatty acids (PUFA) is just as possible as encapsulation of essential oils and other active, sensitive substances to be protected. With Glatt APPtec®, a unique technology for spray calcination, it is possible to generate, coat and then calcine particles in a pulsing hot gas stream in a single process step. As a pioneer in fluid bed and spouted bed technologies, Glatt masters these important processes for the formulation and optimization of particle properties through defined spray agglomeration, spray granulation, spray coating or (micro)encapsulation as well as through combinations of these processes. Also in the high temperature range. Glatt supports the product idea from the early phase of product formulation through process development to scale-up to production scale. Under the leadership of the Glatt Process & Plant Engineering teams, customized production plants for nutrition, fine chemicals, pharmaceuticals, and biotech applications are successfully planned and commissioned. Worldwide. Whether based on powder synthesis, fluid bed or spouted bed technology, Glatt also offers certified contract manufacturing for customers without their own production capacities.

Inspiring the nutraceuticals industry to innovate, connect and grow sustainably Innovation and connection Vitafoods is constantly evolving so that the nutraceuticals industry can stay ahead of the curve. We aim to inspire innovation by showcasing cutting-edge solutions and products and enable collaboration by creating new ways for the nutraceuticals community to connect.

By determining the quality of the end product, it is essential to select the most suitable technology approach. Individually adjusted coating parameters By determining the quality of the end product, particle coating is a critical step in many manufacturing processes. To achieve optimum results, it is essential to select the most suitable approach and, to do this, the specific properties of the raw materials, the required functionality of the coating and the intended application must all be considered. The most important aspects to think about when coating functionalised particles are outlined below. From the very beginning, those involved in process and product development must define the target parameters, the desired product properties and identify the technological and commercial conditions. Based on these criteria, a suitable technology can then be selected for production. Typically, this is an incremental process that, based on an initial concept, investigates different production variants. The aim is to optimise the process in terms of product properties and costs.…

The desired end product properties can make a difference when choosing between spray drying or spray granulation Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most effective process will often be dictated by the desired properties of the final particles and the specific application. Glatt Ingenieurtechnik has a thorough understanding of both techniques and has a long history of designing fluid bed systems that are tailored to individual customer products. Drying solids-laden liquids is frequently used in industry to convert products into a more manageable form and enable their storage at ambient temperatures. The resulting bulk materials are not only more stable than the liquid raw materials, they also have lower weights and smaller volumes, significantly reducing transportation and storage costs as well as any handling issues. To dry liquids as quickly as possible, spraying them into a hot air stream (spray drying) is very effective. It has been used for decades to quickly and cost-efficiently dry large-volume…

Using fluidized bed spray agglomeration, particle size distribution, particle structure and particle properties can be specifically adjusted and improved. Spray agglomeration of plant-based milk alternatives for perfect wetting and dispersing properties Powdery substances often cause problems during dosing, filling and transport because of their high dust content and poor flowability. Low solubilities and dispersing properties also impair the application of the end product. With the help of fluidised bed spray agglomeration, the size distribution and structure of difficult-to-process particles can be specifically adjusted and improved. According to a study by the Research and Markets Institute, the global market for plant-based milk alternatives will grow at an estimated annual rate of 9.9% until 2025 (vegconomist 2020). Market shares of almond and soy milk are expected to grow particularly rapidly, at 40% and 37% respectively. At the same time, the application and use of powdered products is increasing. Benefits include the fact that less packaging required, which is more sustainable, and transport is both easier…

With short time-to-market: Particle and functional design from the fluid bed market leader The Glatt Group’s customers benefit from bundled expertise in particle design – from the initial feasibility test, through scale-up, to validation of the production process. Glatt offers suitable solutions for every variant and, if required, also implements customer-specific processes. Contract manufacturing has to fulfill very varied requirements. Some companies permanently outsource their production and permanently request large quantities. Others require flexible production slots to compensate for highly fluctuating requirements in terms of volume. Often, a mature product idea exists, but the innovators do not yet have the suitable technology. For the production and refinement of solid product formulations, a wide variety of tasks are commonplace: from nanodispersed powders for high-tech applications, to matrix-encapsulated feed and food additives in granule and pellet form, to products with a modified release of active ingredients. Contract manufacturing…

Plant-based functional ingredients behave differently than manufacturers of nutraceuticals and cosmetic products would like. Double microencapsulation can help them to overcome bioavailability and solubility challenges Plant-based functional ingredients behave differently than manufacturers of nutraceuticals and cosmetic products would like. Innovative processes such as double microencapsulation can help them to overcome bioavailability and solubility challenges. Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great promise in both consumer and scientific applications.1 Hewlings and Kalman reported that the reason for this is because of the medicinal properties of this rhizomatous perennial plant (Curcuma longa) from the ginger family, which have been known for thousands of years.2 In Asian countries, turmeric has traditionally been used as a medicinal plant for its antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer properties.3–5 This sought-after ingredient is not only…

Plant engineers should “go the extra mile” to ensure the safe operation of process facilities Manufacturers in the bulk material industriy can profit, if the engineering and construction company not only develops tailor made solutions, but is a manufacturer itself. Toll manufacturing sharpens the view for the obligations, dutys and challenges on the manufacturing and operation side. Manufacturers need to pay higher attention to product safety, fire and explosion protection, plant and operator safety (occupational health) as well as environmental protection, than required from the engineering and construction side. Being a toll manufacturer themself, Glatt is incorporating the operational experience into the design of their process plants, beyond legal and regulatory requirements. Plant manufacturers and operators must comply with strict operational demands and legal regulations, some of which overlap or must be apportioned to the appropriate party. For the plant manufacturer, examples include conformity procedures — such as risk analyses in accordance with…

An overview of essential oil and vitamin case studies Phytochemicals are increasingly found in many food, chemical and agricultural items. Product and process optimization is becoming ever-more important in all of these industries, with a focus on quality, manufacturing efficiency, stability and formulation costs. Essential oils are volatile substances with a relatively high vapor pressure; they are susceptible to oxidation and light and may change or may even lose their properties when directly exposed to stressors. Like other sensitive, volatile, odor- or taste-intensive liquid active ingredients, they must therefore be protected from the environment or vice versa. For this protection and to simplify handling — as well as for better dosage and targeted release — these substances are therefore progressively offered and used in encapsulated and/or free-flowing forms. Various processes can be used to deliver products with a compact structure. During process development, the most suitable procedures and equipment…

Fluidised bed and spouted bed processes offer manufacturers almost unlimited possibilities in terms of optimised particle design and the functionalisation of ingredients, the properties of which can be fine-tuned Fluidised bed and spouted bed processes by Glatt offer manufacturers almost unlimited possibilities in terms of optimised particle design and the functionalisation of ingredients, the properties of which can be fine-tuned using spray granulation, agglomeration, microencapsulation and coating. The consumer demand for fortified products is constantly growing and has been well received by end users. The form in which health-promoting probiotics, dietary fibres or antioxidants are consumed depends on both the preferences and everyday habits of the individual: some prefer sports drinks, protein bars or enriched iced tea, whereas others favour more direct dosage forms, such as effervescent tablets, sachets or capsules. However, although the manufacturing processes associated with these products present numerous challenges, a universal requirement is that functional ingredients must be stable during storage, precisely dosed, dissolve quickly or have a depot effect. Key…

Enhanced efficacy of coenzyme Q10, curcuma or similar ingredients To enable the body to absorb essential nutrients While this issue is the most essential for the formulation of pharmaceutical dosage forms, as it determines the efficacy of the drug, studies on the uptake of dietary supplements are only just beginning. However, water-insoluble substances cannot be absorbed by the body and must therefore be converted into a soluble micellar structure. In liquid form, these formulations have a limited shelflife stability, so a drying step follows, which produces a wide variety of product forms ranging from readily mixable powders to dust-free, easily soluble granules or compact, defined pellets. The moderate and precisely controllable process temperature in the fluidized bed or spouted bed is particularly suitable for sensitive active ingredients. Coenzyme Q10, curcuma or similar substances are typical candidates for improving bioavailability. The process steps required for this can be completely tested from micelle formation to…

Fast solubility. Low bulk density. Good flowability. Good dosability. Transform your powders into porous, dust-free, easy-flowing and homogeneous granules by means of Glatt fluid bed spray agglomeration. Fluid bed spray agglomeration of fine powders enables the production of porous granules with a defined particle specification. Due to the relatively low mechanical forces during agglomeration in the fluid bed, agglomerates with a capillary structure, porous surfaces and only a low dust content are produced. These are the best prerequisites for good wettability. These products therefore have excellent dispersibility and are soluble in water. They have a low bulk density and their particle size distribution – usually between 0.2 and 2.5 mm – can also be controlled. The interconnected powder particles are homogeneously distributed and improve flowability and reduce electrostatic charging. A wide range of effects can be achieved via the choice of spray medium, its composition and concentration. Simply changing the viscosity of the…

Targeted control of product properties for fast and improved solubility of protein powders. Several processes. ONE process step only. Perfect solubility. Targeted control of product properties. Proteins are a common ingredient in powder mixes for sports drinks and other protein drinks. Isolating them from complex animal or vegetable sources and then preserving them by drying in a spray tower produces a fine powder with low solubility. Dry your solution in one step to perfectly soluble agglomerates with our fluidized bed technology. Several processes in one step for improved solubility of proteins The combination of our processes such as spray granulation and spray agglomeration in just one fluidized bed apparatus offers maximum flexibility for influencing product properties. In the first zone of the apparatus, liquid droplets dry to form powder particles, similar to the drying process in the spray tower. This initial layer is built up into granules in the other zones by spraying. Spray droplets hit the particles several times and spread across the…

Optimal Animal Feed Mixtures: Taste masking. Homogeneous compounds. Processing enzymes, organic acids or essential oils. Gentle processing of animal feed additives Feed additives for large livestock today fulfill a wide variety of tasks. Weight gain in fattening cattle, increasing milk yield or reducing phosphate excretion are just some of the issues in the feed industry. Enzymes, organic acids or essential oils perform specific tasks. Since the ban on prophylactic antibiotic administration, bactericidal oils have become an integral part of feeds. All these products are usually used in feed mixtures and must therefore be robust and free-flowing. Glatt fluid bed and spouted bed technology Processes such as spray stiffening, a special variant of spray granulation, embed oleoresins and other essential oils in a fatty matrix, turning them into compact additives that mix well. Coating processes allow taste masking of bad smelling and tasting active ingredients. In addition, active substances are also often sensitive to temperature or oxidation and, with a protective coating, are given…

Protection for essential oils, carotenoids, flavors and hydrophobic substances and other active ingredients by micro encapsulation Protecting and drying hydrophobic substances by micro encapsulation Essential oils, carotenoids, flavors or even hydrophobic plant substances are challenging candidates in terms of formulation and process due to their chemical structure. Such substances are usually extremely sensitive to oxidation and to higher temperatures. For many applications, these substances are needed in solid formulations, for example in flavored teas and dessert mixes or as essential oils, neutral in taste and stable over time as additives in baby food. The micro encapsulation process combines the inclusion of hydrophobic substances in a matrix with granulation and drying. In the first process step, the oil is emulsified and encapsulated with an encapsulation material that protects against oxidation – such as modified starches, hydrocolloids or even proteins. Stabilization of the emulsion has a decisive influence on product quality. It prevents the microcapsules from being destroyed…