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Researchers at Trudell Medical International (London ON, Canada) are using the new Malvern Spraytec particle size analyzer in the study of nebulizer performance. Spraytec, equipped with an inhalation cell, allows characterization of nebulizer sprays under conditions representative of their use. At TMI, the system is being used in the development of new products such as the AeroEclipse® II breath-actuated nebulizer (BAN).

The original AeroEclipse® BAN, was the first mechanically-operated small volume BAN with dosimetric capability, providing a near constant delivery rate of medication from a variety of formulations and volume fills. This nebulizer required an inhalation flow rate close to 25 L/min to operate the breath-actuation mechanism. The second generation AeroEclipse® II BAN now actuates at flow rates as low as 15 L/min, making it potentially more suitable for younger patients.

Dr Jolyon Mitchell, Scientific Director, said the team had clear reasons for selecting the Spraytec system. “Based on initial testing with a widely used formulation, it may indeed be suitable for a wide range of pharmaceutical applications. Equally important for nebulizer studies is the inhalation cell which draws sample through the measurement zone at a rate designed to simulate the inhalation process.”