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Malvern Instruments has introduced an Inhalation Cell accessory for its new generation Spraytec laser diffraction particle size analyzer. Aerosol delivery is becoming increasingly important for a wide variety of therapeutic materials, providing a means of rapid drug delivery with high bioavailability. The Spraytec’s new Inhalation Cell is designed to support pharmaceutical development by enabling the rapid characterization of systems such as dry powder inhalers (DPIs), metered dose inhalers (MDIs) and nebulizers. Measurements can be carried out under fixed or varying flow rate conditions, so the system is ideal for the optimization of API delivery by the inhalation route.

The new Inhalation Cell fits easily on to the Spraytec optical bench and is readily dismantled for cleaning. Once the cell is fitted, all the benefits of the Spraytec system become available to inhaler developers, delivering real-time, high-speed particle size measurements for the complete characterization of continuous and pulsed spray events. With a data acquisition rate of 10 kHz – in practice a 100-microsecond time resolution – it allows highly accurate analysis of the dynamics of spray atomization and dispersion, so that even the rapid changes in particle size that take place during inhaler operation can be followed.