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A new high sensitivity particle image analyzer from Malvern Instruments incorporates the latest Nikon CFI60 optics and a high resolution digital camera to deliver particle size and shape data and images. Based on digital image analysis and automated microscopy, the new Morphologi G2 measures particle size across a wide range from 0.5 to 1000 microns, using circle equivalent diameter, and employs a variety of parameters for particle shape analysis. This allows determination and quantification of even subtle differences between particles. Since every particle in a sample can be individually measured and recorded, the analyzer also has applications in counting and foreign particle detection.

The Morphologi G2 particle image analyzer provides both microscope-quality images and statistically significant data through the rapid analysis of hundreds of thousands of particles. The ability to see and record images of all particles allows visual verification and detection of phenomena such as broken particles, agglomerates and the presence of fines. Full automation using Standard Operating Procedures (SOP) eliminates any user bias inherent in manual microscopy methods, and enables straightforward method development and easy electronic transfer.

Automatic calibration, conformance to 21CFR part 11 requirements and the availability of full IQ/OQ documentation ensure that the system is accurate and repeatable, and all data is secure and validated. As well as SOP-driven, automated operation, Morphologi’s powerful software package enables the generation of customer reports, allows the user to sort, filter and classify captured particle images, plot trends between multiple records, and overplot and compare multiple data sets.